PDBe 5ms4

X-ray diffraction
2.1Å resolution

Kallikrein-related peptidase 8 leupeptin inhibitor complex


Function and Biology Details

Reaction catalysed:
Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Kallikrein-8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 228 amino acids
Theoretical weight: 24.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O60259 (Residues: 33-260; Coverage: 98%)
Gene names: KLK8, NRPN, PRSS19, TADG14, UNQ283/PRO322
Sequence domains: Trypsin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 83.103Å b: 46.045Å c: 103.349Å
α: 90° β: 91.4° γ: 90°
R R work R free
0.239 0.212 0.259
Expression system: Escherichia coli