X-ray diffraction
2Å resolution

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 696 amino acids
Theoretical weight: 77.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 158.296Å b: 81.058Å c: 105.69Å
α: 90° β: 131.1° γ: 90°
R R work R free
0.196 0.195 0.219
Expression system: Homo sapiens