X-ray diffraction
2.5Å resolution

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 696 amino acids
Theoretical weight: 77.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: C2
Unit cell:
a: 162.395Å b: 78.23Å c: 111.796Å
α: 90° β: 127.2° γ: 90°
R R work R free
0.212 0.211 0.233
Expression system: Homo sapiens