5mr5

X-ray diffraction
2Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurturin Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99748 (Residues: 96-197; Coverage: 57%)
Gene name: NRTN
Sequence domains: Transforming growth factor beta like domain
GDNF family receptor alpha-2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 216 amino acids
Theoretical weight: 24.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O00451 (Residues: 147-362; Coverage: 49%)
Gene names: GDNFRB, GFRA2, RETL2, TRNR2
Sequence domains: GDNF/GAS1 domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 52.07Å b: 120.3Å c: 78.67Å
α: 90° β: 98.46° γ: 90°
R-values:
R R work R free
0.206 0.204 0.243
Expression systems:
  • Escherichia coli
  • Cricetulus griseus