5mr4

X-ray diffraction
2.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurturin Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99748 (Residues: 96-197; Coverage: 57%)
Gene name: NRTN
Sequence domains: Transforming growth factor beta like domain
GDNF family receptor alpha-2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 458 amino acids
Theoretical weight: 50.93 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O00451 (Residues: 1-458; Coverage: 99%)
Gene names: GDNFRB, GFRA2, RETL2, TRNR2
Sequence domains: GDNF/GAS1 domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 77.81Å b: 125.811Å c: 82.722Å
α: 90° β: 101.93° γ: 90°
R-values:
R R work R free
0.196 0.195 0.22
Expression systems:
  • Escherichia coli
  • Cricetulus griseus