X-ray diffraction
3.25Å resolution

Crystal structure of dCK mutant C3S in complex with masitinib and UDP


Function and Biology Details

Reactions catalysed:
ATP + deoxyadenosine = ADP + dAMP
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Deoxycytidine kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 289 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43212
Unit cell:
a: 88.33Å b: 88.33Å c: 342.53Å
α: 90° β: 90° γ: 90°
R R work R free
0.219 0.215 0.277
Expression system: Escherichia coli