Solution NMR

Solution structure of the cinaciguat bound human beta1 H-NOX.

Source organism: Homo sapiens
Entry authors: Matzapetakis M, Saraiva IH

Function and Biology Details

Reaction catalysed:
GTP = 3',5'-cyclic GMP + diphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Guanylate cyclase soluble subunit beta-1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q02153 (Residues: 1-188; Coverage: 30%)
Gene names: GUC1B3, GUCSB3, GUCY1B1, GUCY1B3
Sequence domains: Haem-NO-binding

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: simulated annealing
Chemical shifts: BMR34077  
Expression system: Escherichia coli