PDBe 5mmw

X-ray diffraction
2.7Å resolution

Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 6 and a fragment of the TIF2 co-activator.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 229-457; Coverage: 50%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.02 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P43212
Unit cell:
a: 67.489Å b: 67.489Å c: 108.639Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.2 0.253
Expression systems:
  • Escherichia coli
  • Not provided