PDBe 5mlj

X-ray diffraction
1.8Å resolution

Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one


Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Histone acetyltransferase KAT2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q92830 (Residues: 729-837; Coverage: 13%)
Gene names: GCN5, GCN5L2, KAT2A
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 45.63Å b: 74Å c: 76.31Å
α: 90° β: 90° γ: 90°
R R work R free
0.169 0.167 0.211
Expression system: Escherichia coli