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Crystal structure of rat prorenin

X-ray diffraction
2.6Å resolution
PDB entry 5mlg coloured by chain, front view.
PDB entry 5mlg coloured by chain, side view.
PDB entry 5mlg coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Renin
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Multimeric state: monomeric
Accessible surface area: 15798.7 Å2
Buried surface area: 273.73 Å2
Dissociation area: 136.86 Å2
Dissociation energy (ΔGdiss): -5.76 kcal/mol
Dissociation entropy (TΔSdiss): 2.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140124

Macromolecules

Renin
Chain: A
Length: 389 amino acids
Theoretical weight: 42.87 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P08424 (Residues: 22-402; Coverage: 100%)
Gene names: Ren, Ren1
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Renin in PDB entry 5mlg, assembly 1, front view.
Renin in PDB entry 5mlg, assembly 1, side view.
Renin in PDB entry 5mlg, assembly 1, top view.
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