› 5ml3

X-ray diffraction
1.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Chain: B
Molecule details ›
Chain: B
Length: 149 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43924 (Residues: 2-150; Coverage: 99%)
Gene names: PDE6D, PDED
Sequence domains: GMP-PDE, delta subunit
Structure domains: GMP phosphodiesterase, delta subunit

Ligands and Environments

1 bound ligand:
Ligand DL3 1 x DL3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 56.01Å b: 56.01Å c: 115.09Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.189 0.203
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Mechanism of activation and the rewired network: New drug design concepts.
Nussinov et al. (2022)
18 more

2 mentions without citation

Inhibition of Nonfunctional Ras.
Nussinov et al. (2021)
1 more