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Kinase domain of human EphB1 bound to a quinazoline-based inhibitor

X-ray diffraction
2.14Å resolution
PDB entry 5mja coloured by chain, front view.
PDB entry 5mja coloured by chain, side view.
PDB entry 5mja coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ephrin type-B receptor 1
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Multimeric state: monomeric
Accessible surface area: 13361.96 Å2
Buried surface area: 169.56 Å2
Dissociation area: 84.78 Å2
Dissociation energy (ΔGdiss): 11.08 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157092
Assembly 2
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Assembly Name: Ephrin type-B receptor 1
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Multimeric state: monomeric
Accessible surface area: 13763.17 Å2
Buried surface area: 86.16 Å2
Dissociation area: 43.08 Å2
Dissociation energy (ΔGdiss): 4.01 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157092

Macromolecules

Ephrin type-B receptor 1
Chains: A, B
Length: 305 amino acids
Theoretical weight: 34.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54762 (Residues: 602-896; Coverage: 31%)
Gene names: ELK, EPHB1, EPHT2, HEK6, NET
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Ephrin type-B receptor 1 in PDB entry 5mja, assembly 1, front view.
Ephrin type-B receptor 1 in PDB entry 5mja, assembly 1, side view.
Ephrin type-B receptor 1 in PDB entry 5mja, assembly 1, top view.
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