5mja

X-ray diffraction
2.14Å resolution

Kinase domain of human EphB1 bound to a quinazoline-based inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-B receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 305 amino acids
Theoretical weight: 34.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54762 (Residues: 602-896; Coverage: 31%)
Gene names: ELK, EPHB1, EPHT2, HEK6, NET
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 101.806Å b: 101.806Å c: 157.14Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.236
Expression system: Escherichia coli BL21(DE3)