5mho

X-ray diffraction
2.92Å resolution

FXIIIa in complex with the inhibitor ZED2369

Released:
Entry authors: Stieler M, Heine A, Klebe G

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIII A chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 738 amino acids
Theoretical weight: 84.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00488 (Residues: 2-732; Coverage: 100%)
Gene names: F13A, F13A1
Sequence domains:
Structure domains:
inhibitor ZED2369 Chains: G, H
Molecule details ›
Chains: G, H
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 56.555Å b: 80.508Å c: 102.904Å
α: 88.2° β: 76.91° γ: 82.23°
R-values:
R R work R free
0.219 0.217 0.248
Expression systems:
  • Spodoptera frugiperda
  • Not provided