5mgk

X-ray diffraction
2.3Å resolution

Crystal Structure of BAZ2A bromodomain in complex with 4-propionyl-pyrrole derivative 2

Released:
Source organism: Homo sapiens
Primary publication:
Discovery of BAZ2A bromodomain ligands.
Eur J Med Chem 139 564-572 (2017)
PMID: 28837921

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2A Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIF9 (Residues: 1796-1898; Coverage: 5%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P3121
Unit cell:
a: 95.239Å b: 95.239Å c: 32.96Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.236
Expression system: Escherichia coli