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Cathepsin B in complex with DARPin 81

X-ray diffraction
1.81Å resolution
PDB entry 5mbl coloured by chain, front view.
PDB entry 5mbl coloured by chain, side view.
PDB entry 5mbl coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin B heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 17503.38 Å2
Buried surface area: 1897.92 Å2
Dissociation area: 873.01 Å2
Dissociation energy (ΔGdiss): -5.5 kcal/mol
Dissociation entropy (TΔSdiss): 12.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139797

Macromolecules

Cathepsin B
Chain: A
Length: 256 amino acids
Theoretical weight: 28.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07858 (Residues: 78-333; Coverage: 80%)
Gene names: CPSB, CTSB
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
Cathepsin B in PDB entry 5mbl, assembly 1, front view.
Cathepsin B in PDB entry 5mbl, assembly 1, side view.
Cathepsin B in PDB entry 5mbl, assembly 1, top view.
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DARPin 81
Chain: B
Length: 171 amino acids
Theoretical weight: 17.87 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
InterPro:
CATH: Ankyrin repeat-containing domain
DARPin 81 in PDB entry 5mbl, assembly 1, front view.
DARPin 81 in PDB entry 5mbl, assembly 1, side view.
DARPin 81 in PDB entry 5mbl, assembly 1, top view.
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