› 5mag

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maternal embryonic leucine zipper kinase Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 40.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14680 (Residues: 2-340; Coverage: 52%)
Gene names: KIAA0175, MELK
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand 7KC 1 x 7KC
Ligand DMS 1 x DMS
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 61.18Å b: 62.81Å c: 94.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.252
Expression system: Spodoptera frugiperda

Quick links

Citations

47 review citations

Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition.
East et al. (2022)
46 more

2 mentions without citation

The target landscape of clinical kinase drugs.
Klaeger et al. (2017)
1 more