5m8r

X-ray diffraction
2.4Å resolution

Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with mimosine

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
5,6-dihydroxyindole-2-carboxylic acid oxidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 446 amino acids
Theoretical weight: 50.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P17643 (Residues: 25-470; Coverage: 87%)
Gene names: CAS2, TYRP, TYRP1, TYRRP
Sequence domains: Common central domain of tyrosinase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, FUC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P212121
Unit cell:
a: 89.353Å b: 139.727Å c: 190.951Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.249
Expression system: Spodoptera frugiperda