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Translation initiation factor 4E in complex with (RP)-m2(7,2'O)GppSepG mRNA 5' cap analog (beta-Se-ARCA D1)

X-ray diffraction
1.68Å resolution
PDB entry 5m7x coloured by chain, front view.
PDB entry 5m7x coloured by chain, side view.
PDB entry 5m7x coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9491.7 Å2
Buried surface area: 277.09 Å2
Dissociation area: 138.55 Å2
Dissociation energy (ΔGdiss): 1.64 kcal/mol
Dissociation entropy (TΔSdiss): 0.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 2
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9464.09 Å2
Buried surface area: 264.03 Å2
Dissociation area: 132.01 Å2
Dissociation energy (ΔGdiss): 1.48 kcal/mol
Dissociation entropy (TΔSdiss): 0.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 3
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9280.47 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 4
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9389.45 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938

Macromolecules

Eukaryotic translation initiation factor 4E
Chains: A, B, C, D
Length: 190 amino acids
Theoretical weight: 22.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63073 (Residues: 28-217; Coverage: 88%)
Gene name: Eif4e
Pfam: Eukaryotic initiation factor 4E
InterPro:
CATH: RNA Cap, Translation Initiation Factor Eif4e
Eukaryotic translation initiation factor 4E in PDB entry 5m7x, assembly 1, front view.
Eukaryotic translation initiation factor 4E in PDB entry 5m7x, assembly 1, side view.
Eukaryotic translation initiation factor 4E in PDB entry 5m7x, assembly 1, top view.
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