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Structure of the human SRP S domain with SRP72 RNA-binding domain

X-ray diffraction
3.4Å resolution
PDB entry 5m73 coloured by chain, front view.
PDB entry 5m73 coloured by chain, side view.
PDB entry 5m73 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules
1 distinct RNA molecule

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Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 42092.67 Å2
Buried surface area: 12705.46 Å2
Dissociation area: 910.6 Å2
Dissociation energy (ΔGdiss): 2.44 kcal/mol
Dissociation entropy (TΔSdiss): 11.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131215
Assembly 2 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 41947.62 Å2
Buried surface area: 10377.32 Å2
Dissociation area: 1,492.14 Å2
Dissociation energy (ΔGdiss): 19.75 kcal/mol
Dissociation entropy (TΔSdiss): 13.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131215

Macromolecules

Signal recognition particle 19 kDa protein
Chains: B, F
Length: 128 amino acids
Theoretical weight: 14.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09132 (Residues: 11-118; Coverage: 75%)
Gene name: SRP19
Pfam: SRP19 protein
InterPro:
CATH: Signal recognition particle, SRP19-like subunit
Signal recognition particle 19 kDa protein in PDB entry 5m73, assembly 2, front view.
Signal recognition particle 19 kDa protein in PDB entry 5m73, assembly 2, side view.
Signal recognition particle 19 kDa protein in PDB entry 5m73, assembly 2, top view.
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Signal recognition particle subunit SRP68
Chains: C, G
Length: 203 amino acids
Theoretical weight: 24.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHB9 (Residues: 60-254; Coverage: 31%)
Gene name: SRP68
Pfam: RNA-binding signal recognition particle 68
InterPro:
CATH: Signal recognition particle, SRP68 subunit, RNA-binding domain
Signal recognition particle subunit SRP68 in PDB entry 5m73, assembly 2, front view.
Signal recognition particle subunit SRP68 in PDB entry 5m73, assembly 2, side view.
Signal recognition particle subunit SRP68 in PDB entry 5m73, assembly 2, top view.
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Signal recognition particle subunit SRP72
Chains: D, H
Length: 158 amino acids
Theoretical weight: 17.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O76094 (Residues: 512-668; Coverage: 23%)
Gene name: SRP72
Pfam: SRP72 RNA-binding domain
InterPro:
Signal recognition particle subunit SRP72 in PDB entry 5m73, assembly 2, front view.
Signal recognition particle subunit SRP72 in PDB entry 5m73, assembly 2, side view.
Signal recognition particle subunit SRP72 in PDB entry 5m73, assembly 2, top view.
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RNA chains A, E
Name: Human gene for small cytoplasmic 7SL RNA (7L30.1)
Representative chains: A, E
Length: 145 nucleotides
Theoretical weight: 47.2 KDa
Rfam: Metazoan signal recognition particle RNA
Human gene for small cytoplasmic 7SL RNA (7L30.1) in PDB entry 5m73, assembly 2, front view.
Human gene for small cytoplasmic 7SL RNA (7L30.1) in PDB entry 5m73, assembly 2, side view.
Human gene for small cytoplasmic 7SL RNA (7L30.1) in PDB entry 5m73, assembly 2, top view.
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