Function and Biology

Pseudo-atomic model of microtubule-bound S.pombe kinesin-5 motor domain in the AMPPNP state (based on cryo-electron microscopy experiment): the N-terminus conformation allows formation of a cover neck bundle.

Source organisms:
Biochemical function: nucleotide binding
Biological process: microtubule-based process
Cellular component: microtubule

Sequence families

Pfam Protein families (Pfam)
PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
1 copy of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1D chain in PDB 5m5i.
2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta-2B chain in PDB 5m5i.

PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
1 copy of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1D chain in PDB 5m5i.
2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta-2B chain in PDB 5m5i.

PF00225
Domain description: Kinesin motor domain
Occurring in:
  1. Kinesin-like protein cut7
1 copy of Pfam domain PF00225 (Kinesin motor domain) in Kinesin-like protein cut7 in PDB 5m5i.

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1D chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta-2B chain
IPR001752
Domain description: Kinesin motor domain
Occurring in:
  1. Kinesin-like protein cut7
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR037103
Domain description: Tubulin/FtsZ, C-terminal domain superfamily
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1D chain
  2. Tubulin beta-2B chain
IPR027640
Domain description: Kinesin-like protein
Occurring in:
  1. Kinesin-like protein cut7
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Kinesin-like protein cut7
IPR036961
Domain description: Kinesin motor domain superfamily
Occurring in:
  1. Kinesin-like protein cut7