PDBe 5m5e

X-ray diffraction
2.3Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-2 receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 233 amino acids
Theoretical weight: 26.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14784 (Residues: 27-240; Coverage: 41%)
Gene names: IL15RB, IL2RB
Sequence domains: Interleukin-2 receptor subunit beta N-terminal domain 1
Cytokine receptor common subunit gamma Chain: C
Molecule details ›
Chain: C
Length: 259 amino acids
Theoretical weight: 30.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31785 (Residues: 23-262; Coverage: 69%)
Gene name: IL2RG
Sequence domains: Interleukin-6 receptor alpha chain, binding
Interleukin-2 Chain: D
Molecule details ›
Chain: D
Length: 160 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60568 (Residues: 8-14, 15-153; Coverage: 100%)
Gene name: IL2

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 127.965Å b: 127.965Å c: 135.073Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.235
Expression system: Homo sapiens