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HTRA2 A141S mutant structure

X-ray diffraction
1.7Å resolution
PDB entry 5m3o coloured by chain, front view.
PDB entry 5m3o coloured by chain, side view.
PDB entry 5m3o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease HTRA2, mitochondrial
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Multimeric state: homo trimer
Accessible surface area: 35617.13 Å2
Buried surface area: 6752.87 Å2
Dissociation area: 3,278.2 Å2
Dissociation energy (ΔGdiss): 2.82 kcal/mol
Dissociation entropy (TΔSdiss): 27.62 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-128934

Macromolecules

Serine protease HTRA2, mitochondrial
Chain: A
Length: 334 amino acids
Theoretical weight: 36.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43464 (Residues: 134-458; Coverage: 71%)
Gene names: HTRA2, OMI, PRSS25
Pfam:
InterPro:
CATH:
Serine protease HTRA2, mitochondrial in PDB entry 5m3o, assembly 1, front view.
Serine protease HTRA2, mitochondrial in PDB entry 5m3o, assembly 1, side view.
Serine protease HTRA2, mitochondrial in PDB entry 5m3o, assembly 1, top view.
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