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Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD

X-ray diffraction
2.5Å resolution
PDB entry 5m3h coloured by chain, front view.
PDB entry 5m3h coloured by chain, side view.
PDB entry 5m3h coloured by chain, top view.
Source organisms:
Assembly composition:
hetero heptamer (preferred)
Entry contents: 4 distinct polypeptide molecules
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero heptamer
Accessible surface area: 90129.06 Å2
Buried surface area: 46508.94 Å2
Dissociation area: 338.17 Å2
Dissociation energy (ΔGdiss): 1.16 kcal/mol
Dissociation entropy (TΔSdiss): 6.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-124813

Macromolecules

Polymerase acidic protein
Chain: A
Length: 728 amino acids
Theoretical weight: 84.24 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: H6QM92 (Residues: 1-713; Coverage: 100%)
Gene name: PA
Pfam: Influenza RNA-dependent RNA polymerase subunit PA
InterPro:
Polymerase acidic protein in PDB entry 5m3h, assembly 1, front view.
Polymerase acidic protein in PDB entry 5m3h, assembly 1, side view.
Polymerase acidic protein in PDB entry 5m3h, assembly 1, top view.
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RNA-directed RNA polymerase catalytic subunit
Chain: B
Length: 776 amino acids
Theoretical weight: 87.94 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: H6QM91 (Residues: 1-756; Coverage: 100%)
Gene name: PB1
Pfam: Influenza RNA-dependent RNA polymerase subunit PB1
InterPro:
RNA-directed RNA polymerase catalytic subunit in PDB entry 5m3h, assembly 1, front view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 5m3h, assembly 1, side view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 5m3h, assembly 1, top view.
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Polymerase basic protein 2
Chain: C
Length: 797 amino acids
Theoretical weight: 90.17 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: H6QM90 (Residues: 1-760; Coverage: 100%)
Gene name: PB2
Pfam:
InterPro:
Polymerase basic protein 2 in PDB entry 5m3h, assembly 1, front view.
Polymerase basic protein 2 in PDB entry 5m3h, assembly 1, side view.
Polymerase basic protein 2 in PDB entry 5m3h, assembly 1, top view.
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DNA-directed RNA polymerase II subunit RPB1
Chains: X, Y
Length: 28 amino acids
Theoretical weight: 3.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P24928 (Residues: 1713-1740; Coverage: 1%)
Gene names: POLR2, POLR2A
Pfam: RNA polymerase Rpb1 C-terminal repeat
InterPro: RNA polymerase II, heptapeptide repeat, eukaryotic
DNA-directed RNA polymerase II subunit RPB1 in PDB entry 5m3h, assembly 1, front view.
DNA-directed RNA polymerase II subunit RPB1 in PDB entry 5m3h, assembly 1, side view.
DNA-directed RNA polymerase II subunit RPB1 in PDB entry 5m3h, assembly 1, top view.
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RNA chain R
Name: RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3')
Representative chains: R
Length: 18 nucleotides
Theoretical weight: 5.58 KDa
RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') in PDB entry 5m3h, assembly 1, front view.
RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') in PDB entry 5m3h, assembly 1, side view.
RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') in PDB entry 5m3h, assembly 1, top view.
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RNA chain V
Name: RNA 5'-pAGUAGUAACAAGAGGG
Representative chains: V
Length: 16 nucleotides
Theoretical weight: 5.25 KDa
RNA 5'-pAGUAGUAACAAGAGGG in PDB entry 5m3h, assembly 1, front view.
RNA 5'-pAGUAGUAACAAGAGGG in PDB entry 5m3h, assembly 1, side view.
RNA 5'-pAGUAGUAACAAGAGGG in PDB entry 5m3h, assembly 1, top view.
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