5m2x

X-ray diffraction
4.99Å resolution

Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033)

Released:
Source organism: Zika virus

Function and Biology Details

Reactions catalysed:
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NS5 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 914 amino acids
Theoretical weight: 104.33 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0X8GJ44 (Residues: 2521-3423; Coverage: 26%)
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 191.06Å b: 192.06Å c: 407.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.227 0.276
Expression system: Escherichia coli