5m23

X-ray diffraction
1.97Å resolution

Modulation of MLL1 Methyltransferase Activity

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 434 amino acids
Theoretical weight: 48.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 80.553Å b: 86.098Å c: 40.407Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.214
Expression system: Escherichia coli K-12