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X-ray diffraction
1.2Å resolution

Cholera toxin El Tor B-pentamer in complex with inhibitor Laura237

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cholera enterotoxin subunit B Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 103 amino acids
Theoretical weight: 11.66 KDa
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Expression system: Vibrio sp.
UniProt:
  • Canonical: P01556 (Residues: 22-124; Coverage: 100%)
Gene names: VC_1456, ctxB, toxB
Sequence domains: Heat-labile enterotoxin beta chain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 102.245Å b: 66.476Å c: 82.401Å
α: 90° β: 116.96° γ: 90°
R-values:
R R work R free
0.197 0.195 0.228
Expression system: Vibrio sp.