› 5lyl

X-ray diffraction
1.83Å resolution

Crystal structure of 1 in complex with tafCPB

Released:
DOI: 10.2210/pdb5lyl/pdb
PDB 5lyl coloured by chain and viewed from the front.
PDB 5lyl coloured by chain and viewed from the side.
PDB 5lyl coloured by chain and viewed from the top.
Source organism: Sus scrofa
Primary publication:
Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
Halland N, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schreuder HA, Kallus C
J. Med. Chem. (2016)
PMID: 27749053

Function and Biology Details

Reaction catalysed: 
Preferential release of a C-terminal lysine or arginine amino acid.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase B Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 34.86 KDa
Source organism: Sus scrofa
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P09955 (Residues: 111-416; Coverage: 76%)
Gene names: CPB, CPB1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand T5F 1 x T5F
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 82.513Å b: 82.513Å c: 95.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.141 0.199
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Carboxypeptidase U (CPU, TAFIa, CPB2) in Thromboembolic Disease: What Do We Know Three Decades after Its Discovery?
Claesen et al. (2021)
1 more