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Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10

X-ray diffraction
2.17Å resolution
PDB entry 5lyh coloured by chain, front view.
PDB entry 5lyh coloured by chain, side view.
PDB entry 5lyh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein mono-ADP-ribosyltransferase PARP14
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Multimeric state: monomeric
Accessible surface area: 9753.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-175097
Assembly 2
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Assembly Name: Protein mono-ADP-ribosyltransferase PARP14
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Multimeric state: monomeric
Accessible surface area: 9802.84 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-175097

Macromolecules

Protein mono-ADP-ribosyltransferase PARP14
Chains: A, B
Length: 193 amino acids
Theoretical weight: 22.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q460N5 (Residues: 1611-1801; Coverage: 11%)
Gene names: BAL2, KIAA1268, PARP14
Pfam: Poly(ADP-ribose) polymerase catalytic domain
InterPro: Poly(ADP-ribose) polymerase, catalytic domain
CATH: Phosphoenolpyruvate Carboxykinase; domain 3
Protein mono-ADP-ribosyltransferase PARP14 in PDB entry 5lyh, assembly 1, front view.
Protein mono-ADP-ribosyltransferase PARP14 in PDB entry 5lyh, assembly 1, side view.
Protein mono-ADP-ribosyltransferase PARP14 in PDB entry 5lyh, assembly 1, top view.
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