X-ray diffraction
2.34Å resolution

Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with palonosetron


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 242 amino acids
Theoretical weight: 27.53 KDa
Source organism: Aplysia californica
Expression system: Spodoptera frugiperda
  • Canonical: Q8WSF8 (Residues: 1-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 72.215Å b: 137.051Å c: 131.249Å
α: 90° β: 93.78° γ: 90°
R R work R free
0.219 0.218 0.245
Expression system: Spodoptera frugiperda