› 5lxb

X-ray diffraction
2.34Å resolution

Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with palonosetron

Released:
DOI: 10.2210/pdb5lxb/pdb
PDB 5lxb coloured by chain and viewed from the front.
PDB 5lxb coloured by chain and viewed from the side.
PDB 5lxb coloured by chain and viewed from the top.
Source organism: Aplysia californica
Primary publication:
Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
Price KL, Lillestol RK, Ulens C, Lummis SC
ACS Chem Neurosci (2016)
PMID: 27656911

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 242 amino acids
Theoretical weight: 27.53 KDa
Source organism: Aplysia californica
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WSF8 (Residues: 1-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

2 bound ligands:
Ligand NAG 8 x NAG
Ligand 7A9 7 x 7A9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 72.215Å b: 137.051Å c: 131.249Å
α: 90° β: 93.78° γ: 90°
R-values:
R R work R free
0.219 0.218 0.245
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction.
Sarapultsev et al. (2018)
5 other articles