5lx3

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.

Released:
Source organism: Homo sapiens
Entry authors: Bertrand T, Marquette JP

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 493 amino acids
Theoretical weight: 55.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 61.51Å b: 107.13Å c: 83.59Å
α: 90° β: 96.69° γ: 90°
R-values:
R R work R free
0.172 0.172 0.211
Expression system: Escherichia coli