X-ray diffraction
1.55Å resolution

Crystal structure of JAK3 in complex with Compound 4 (FM381)


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK3 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P52333 (Residues: 812-1103; Coverage: 26%)
Gene name: JAK3
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 42.029Å b: 62.45Å c: 51.27Å
α: 90° β: 92.88° γ: 90°
R R work R free
0.166 0.163 0.204
Expression system: Spodoptera frugiperda