PDBe 5lvx

X-ray diffraction
2.2Å resolution

Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator

Released:

Function and Biology Details

Reactions catalysed:
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysosomal acid glucosylceramidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 497 amino acids
Theoretical weight: 55.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04062 (Residues: 40-536; Coverage: 100%)
Gene names: GBA, GC, GLUC
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 94.91Å b: 132.281Å c: 103.085Å
α: 90° β: 95.26° γ: 90°
R-values:
R R work R free
0.189 0.189 0.21
Expression system: Homo sapiens