EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- RNA polymerase II-specific DNA-binding transcription factor binding
- histone H2AXS139 kinase activity
- U3 snoRNA binding
- protein domain specific binding
- enzyme binding
- transferase activity
- kinase activity
- ATP binding
- protein binding
- DNA-dependent protein kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- RNA binding
- double-stranded DNA binding
- DNA binding
- nucleotide binding
Biological process:
- positive regulation of double-strand break repair via nonhomologous end joining
- positive regulation of platelet formation
- regulation of hematopoietic stem cell differentiation
- negative regulation of cGAS/STING signaling pathway
- double-strand break repair via alternative nonhomologous end joining
- regulation of cellular response to stress
- regulation of primary metabolic process
- regulation of macromolecule metabolic process
- obsolete regulation of nitrogen compound metabolic process
- regulation of epithelial cell proliferation
- regulation of smooth muscle cell proliferation
- positive regulation of response to stimulus
- rhythmic process
- positive regulation of transcription by RNA polymerase II
- positive regulation of translation
- positive regulation of erythrocyte differentiation
- positive regulation of lymphocyte differentiation
- innate immune response
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- regulation of circadian rhythm
- ribosome biogenesis
- protein modification process
- ectopic germ cell programmed cell death
- small-subunit processome assembly
- T cell receptor V(D)J recombination
- immunoglobulin V(D)J recombination
- V(D)J recombination
- T cell differentiation in thymus
- cellular response to insulin stimulus
- protein destabilization
- mitotic G1 DNA damage checkpoint signaling
- lymphocyte differentiation
- peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- phosphorylation
- telomere capping
- cellular component organization
- response to gamma radiation
- response to ionizing radiation
- intrinsic apoptotic signaling pathway in response to DNA damage
- heart development
- brain development
- DNA damage response
- protein phosphorylation
- chromatin remodeling
- DNA recombination
- double-strand break repair via nonhomologous end joining
- double-strand break repair
- DNA repair
- immune system process
- T cell lineage commitment
- pro-B cell differentiation
- immature B cell differentiation
- B cell lineage commitment
- activation of innate immune response
- negative regulation of protein phosphorylation
- somitogenesis
- telomere maintenance
- maturation of 5.8S rRNA
Cellular component:
- nonhomologous end joining complex
- DNA-dependent protein kinase complex
- protein-DNA complex
- protein-containing complex
- small-subunit processome
- membrane
- DNA-dependent protein kinase-DNA ligase 4 complex
- cytosol
- nucleolus
- transcription regulator complex
- nucleoplasm
- nucleus
- chromatin
- chromosome, telomeric region
Sequence families
Protein families (Pfam)
InterPro annotations
IPR036940
Domain description:
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
Occurring in:
IPR037706
Domain description:
DNA-dependent protein kinase catalytic subunit, catalytic domain
Occurring in:
Occurring in: