5lr1

X-ray diffraction
1.44Å resolution

CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.

Released:
Source organism: Homo sapiens
Entry authors: Vallee F, Dupuy A

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P07900 (Residues: 18-223; Coverage: 28%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: I222
Unit cell:
a: 66.54Å b: 90.68Å c: 98.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.22
Expression system: Escherichia coli BL21