PDBe 5lpu

X-ray diffraction
2.1Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Annexin A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 38.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07355 (Residues: 2-339; Coverage: 100%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D
Sequence domains: Annexin
Protein S100-A4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 104 amino acids
Theoretical weight: 12.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26447 (Residues: 1-101; Coverage: 100%)
Gene names: CAPL, MTS1, S100A4
Sequence domains: S-100/ICaBP type calcium binding domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 71.74Å b: 61.24Å c: 148.16Å
α: 90° β: 88.69° γ: 90°
R-values:
R R work R free
0.182 0.181 0.207
Expression system: Escherichia coli