› 5lk3

X-ray diffraction
1.5Å resolution

Structure of hantavirus envelope glycoprotein Gc in postfusion conformation in presence of 500 mM KCL

Released:
DOI: 10.2210/pdb5lk3/pdb
PDB entry 5lk3 coloured by chain, front view.
PDB entry 5lk3 coloured by chain, side view.
PDB entry 5lk3 coloured by chain, top view.
Source organism: Orthohantavirus hantanense
Primary publication:
Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.
Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Pérez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA
PLoS Pathog 12 e1005813 (2016)
PMID: 27783711

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycoprotein C Chain: A
Molecule details ›
Chain: A
Length: 495 amino acids
Theoretical weight: 54.29 KDa
Source organism: Orthohantavirus hantanense
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P08668 (Residues: 649-1105; Coverage: 41%)
Gene name: GP
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
2 bound ligands:
Ligand K 1 x K
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: R3
Unit cell:
a: 107.141Å b: 107.141Å c: 127.627Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.171 0.201
Expression system: Drosophila melanogaster

Quick links

Citations

6 review citations

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.
Rey et al. (2018)
5 more

2 mentions without citation

Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model.
Duehr et al. (2020)
1 more