› 5ljl

X-ray diffraction
1.6Å resolution

Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target

Released:
DOI: 10.2210/pdb5ljl/pdb
PDB 5ljl coloured by chain and viewed from the front.
PDB 5ljl coloured by chain and viewed from the side.
PDB 5ljl coloured by chain and viewed from the top.
Source organism: Streptococcus pneumoniae TIGR4
Primary publication:
Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.
Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J
OpenAccess logo PLoS ONE 11 e0161020 (2016)
PMID: 27649488

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Flavodoxin Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 16.16 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8DPG4 (Residues: 1-147; Coverage: 100%)
Gene names: flaV, spr1175
Sequence domains: Flavodoxin
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 29.871Å b: 60.707Å c: 61.803Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens.
Salillas et al. (2020)
3 other articles