X-ray diffraction
2.02Å resolution

ATP Phosphoribosyltransferase from Mycobacterium tuberculosis in complex with the allosteric inhibitor L-Histidine


Function and Biology Details

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
ATP phosphoribosyltransferase Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 31.69 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WMN1 (Residues: 1-284; Coverage: 100%)
Gene names: MTCY261.17c, Rv2121c, hisG
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: R32
Unit cell:
a: 117.012Å b: 117.012Å c: 127.332Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.194 0.234
Expression system: Escherichia coli BL21(DE3)