X-ray diffraction
3.5Å resolution

Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 307 amino acids
Theoretical weight: 34.27 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
  • Canonical: P01854 (Residues: 114-421; Coverage: 72%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Low affinity immunoglobulin epsilon Fc receptor soluble form Chains: E, F
Molecule details ›
Chains: E, F
Length: 120 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P06734 (Residues: 165-284; Coverage: 37%)
Gene names: CD23A, CLEC4J, FCE2, FCER2, IGEBF
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 80.52Å b: 85.32Å c: 88.23Å
α: 117.87° β: 90.32° γ: 112.62°
R R work R free
0.266 0.266 0.278
Expression systems:
  • Mus musculus
  • Escherichia coli