› 5lg1

X-ray diffraction
2.7Å resolution

Room temperature structure of human IgG4-Fc from crystals analysed in situ

Released:
DOI: 10.2210/pdb5lg1/pdb
PDB entry 5lg1 coloured by chain, front view.
PDB entry 5lg1 coloured by chain, side view.
PDB entry 5lg1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Room temperature structure of human IgG4-Fc from crystals analysed in situ.
Davies AM, Rispens T, Ooijevaar-de Heer P, Aalberse RC, Sutton BJ
Mol Immunol 81 85-91 (2017)
PMID: 27915153

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01861 (Residues: 114-325; Coverage: 54%)
Gene name: IGHG4
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 73.294Å b: 81.934Å c: 103.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.231
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy.
Wang et al. (2020)
1 more

4 mentions without citation

Laminin α5 guides tissue patterning and organogenesis.
Spenlé et al. (2013)
3 more