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Human 20S proteasome complex with Bortezomib at 2.1 Angstrom

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: proteolysis involved in protein catabolic process
Cellular component: proteasome core complex

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
  8. Proteasome subunit beta type-7
  9. Proteasome subunit beta type-3
  10. Proteasome subunit beta type-2
  11. Proteasome subunit beta type-5
  12. Proteasome subunit beta type-1
  13. Proteasome subunit beta type-4
  14. Proteasome subunit beta type-6
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-4. Showing 1 copy in chain P.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-7. Showing 1 copy in chain Q.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-5. Showing 1 copy in chain R.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-1. Showing 1 copy in chain S.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-3. Showing 1 copy in chain T.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-6. Showing 1 copy in chain G.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-7. Showing 1 copy in chain V.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-3. Showing 1 copy in chain W.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-2. Showing 1 copy in chain J.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-5. Showing 1 copy in chain Y.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-1. Showing 1 copy in chain L.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-4. Showing 1 copy in chain M.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-6. Showing 1 copy in chain BA [auth b].

PF10584
Domain description: Proteasome subunit A N-terminal signature
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-4. Showing 1 copy in chain B.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-7. Showing 1 copy in chain Q.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-5. Showing 1 copy in chain R.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-1. Showing 1 copy in chain S.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-3. Showing 1 copy in chain T.
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-6. Showing 1 copy in chain G.

PF12465
Domain description: Proteasome beta subunits C terminal
Occurring in:
  1. Proteasome subunit beta type-7
The deposited structure of PDB entry 5lf3 contains 2 copies of Pfam domain PF12465 (Proteasome beta subunits C terminal ) in Proteasome subunit beta type-7. Showing 1 copy in chain H.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
  8. Proteasome subunit beta type-7
  9. Proteasome subunit beta type-3
  10. Proteasome subunit beta type-2
  11. Proteasome subunit beta type-5
  12. Proteasome subunit beta type-1
  13. Proteasome subunit beta type-4
  14. Proteasome subunit beta type-6
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
  8. Proteasome subunit beta type-7
  9. Proteasome subunit beta type-3
  10. Proteasome subunit beta type-2
  11. Proteasome subunit beta type-5
  12. Proteasome subunit beta type-1
  13. Proteasome subunit beta type-4
  14. Proteasome subunit beta type-6
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta type-7
  2. Proteasome subunit beta type-3
  3. Proteasome subunit beta type-2
  4. Proteasome subunit beta type-5
  5. Proteasome subunit beta type-1
  6. Proteasome subunit beta type-4
  7. Proteasome subunit beta type-6
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta type-7
  2. Proteasome subunit beta type-5
  3. Proteasome subunit beta type-6
IPR016050
Domain description: Proteasome beta-type subunit, conserved site
Occurring in:
  1. Proteasome subunit alpha type-4
  2. Proteasome subunit beta type-7
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-2
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-1
  7. Proteasome subunit beta type-4
  8. Proteasome subunit beta type-6
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
IPR000426
Domain description: Proteasome alpha-subunit, N-terminal domain
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
IPR016295
Domain description: Proteasome subunit beta 4
Occurring in:
  1. Proteasome subunit beta type-4
IPR035206
Domain description: Proteasome subunit beta 2
Occurring in:
  1. Proteasome subunit beta type-2
IPR033811
Domain description: Proteasome beta 3 subunit
Occurring in:
  1. Proteasome subunit beta type-3
IPR024689
Domain description: Proteasome beta subunit, C-terminal
Occurring in:
  1. Proteasome subunit beta type-7
IPR034642
Domain description: Proteasome subunit alpha6
Occurring in:
  1. Proteasome subunit alpha type-6
IPR035144
Domain description: Proteasome subunit alpha 1
Occurring in:
  1. Proteasome subunit alpha type-1
IPR033812
Domain description: Proteasome subunit alpha5
Occurring in:
  1. Proteasome subunit alpha type-5

Structure domain

CATH CATH domain
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. Proteasome subunit alpha type-2
  2. Proteasome subunit alpha type-4
  3. Proteasome subunit alpha type-7
  4. Proteasome subunit alpha type-5
  5. Proteasome subunit alpha type-1
  6. Proteasome subunit alpha type-3
  7. Proteasome subunit alpha type-6
  8. Proteasome subunit beta type-7
  9. Proteasome subunit beta type-3
  10. Proteasome subunit beta type-2
  11. Proteasome subunit beta type-5
  12. Proteasome subunit beta type-1
  13. Proteasome subunit beta type-4
  14. Proteasome subunit beta type-6
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-4. Showing 1 copy in chain B.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-7. Showing 1 copy in chain Q.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-5. Showing 1 copy in chain D.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-1. Showing 1 copy in chain S.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-3. Showing 1 copy in chain T.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-6. Showing 1 copy in chain G.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-7. Showing 1 copy in chain H.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-3. Showing 1 copy in chain I.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-2. Showing 1 copy in chain J.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-5. Showing 1 copy in chain Y.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-1. Showing 1 copy in chain L.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-4. Showing 1 copy in chain M.
The deposited structure of PDB entry 5lf3 contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-6. Showing 1 copy in chain BA [auth b].

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