Structure analysis

Structure of mammalian respiratory Complex I, class3.

Electron Microscopy
5.6Å resolution
Source organism: Bos taurus
Assembly composition:
hetero 45-mer (preferred)
Entry contents: 44 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 45-mer
Accessible surface area: 327266.99 Å2
Buried surface area: 186076.94 Å2
Dissociation area: 449.33 Å2
Dissociation energy (ΔGdiss): -7.38 kcal/mol
Dissociation entropy (TΔSdiss): 10.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132196

Macromolecules

Chain: A
Length: 115 amino acids
Theoretical weight: 13.06 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03898 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
InterPro:

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Chain: B
Length: 179 amino acids
Theoretical weight: 20.1 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42026 (Residues: 38-216; Coverage: 83%)
Gene name: NDUFS7
Pfam: NADH ubiquinone oxidoreductase, 20 Kd subunit
InterPro:

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Chain: E
Length: 217 amino acids
Theoretical weight: 23.84 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04394 (Residues: 33-249; Coverage: 87%)
Gene name: NDUFV2
Pfam: Thioredoxin-like [2Fe-2S] ferredoxin
InterPro:

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Chain: H
Length: 318 amino acids
Theoretical weight: 35.69 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03887 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, MTND1, NADH1, ND1
Pfam: NADH dehydrogenase
InterPro:

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Chain: I
Length: 176 amino acids
Theoretical weight: 20.22 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42028 (Residues: 37-212; Coverage: 83%)
Gene name: NDUFS8
Pfam: 4Fe-4S dicluster domain
InterPro:

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Chain: J
Length: 175 amino acids
Theoretical weight: 19.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03924 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
InterPro:

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Chain: K
Length: 98 amino acids
Theoretical weight: 10.8 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03902 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
InterPro:

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Chain: N
Length: 347 amino acids
Theoretical weight: 39.27 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03892 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Pfam:
InterPro:

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Chain: O
Length: 314 amino acids
Theoretical weight: 34.01 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P34942 (Residues: 114-341; Coverage: 67%)
Gene name: NDUFA10
Pfam: Deoxynucleoside kinase
InterPro:

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Chain: P
Length: 283 amino acids
Theoretical weight: 24.1 KDa
Source organism: Bos taurus

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Chain: Q
Length: 113 amino acids
Theoretical weight: 9.63 KDa
Source organism: Bos taurus

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Chain: R
Length: 89 amino acids
Theoretical weight: 8.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23934 (Residues: 87-121; Coverage: 28%)
Gene name: NDUFS6
Pfam: Zinc-finger domain
InterPro: Zinc finger, CHCC-type

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Chain: S
Length: 99 amino acids
Theoretical weight: 11.1 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02370 (Residues: 1-99; Coverage: 100%)
Gene name: NDUFA2
Pfam: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
InterPro:

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Chains: T, U
Length: 88 amino acids
Theoretical weight: 10.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P52505 (Residues: 69-156; Coverage: 56%)
Gene name: NDUFAB1
Pfam: Phosphopantetheine attachment site
InterPro:

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Chain: V
Length: 115 amino acids
Theoretical weight: 13.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23935 (Residues: 2-116; Coverage: 99%)
Gene name: NDUFA5
Pfam: ETC complex I subunit conserved region
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

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Chain: W
Length: 127 amino acids
Theoretical weight: 14.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02366 (Residues: 2-128; Coverage: 99%)
Gene name: NDUFA6
Pfam: Complex1_LYR-like
InterPro:

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Chain: X
Length: 164 amino acids
Theoretical weight: 17.62 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42029 (Residues: 6-114; Coverage: 63%)
Gene name: NDUFA8
Pfam: CHCH domain
InterPro:

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Chain: Y
Length: 140 amino acids
Theoretical weight: 14.64 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q8HXG6 (Residues: 2-141; Coverage: 99%)
Gene name: NDUFA11
Pfam: Tim17/Tim22/Tim23/Pmp24 family
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

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Chain: Z
Length: 138 amino acids
Theoretical weight: 14.14 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q95KV7 (Residues: 32-100; Coverage: 48%)
Gene names: GRIM19, NDUFA13
Pfam: GRIM-19 protein
InterPro: GRIM-19

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Chain: a
Length: 70 amino acids
Theoretical weight: 8.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02377 (Residues: 1-70; Coverage: 100%)
Gene name: NDUFA1
Pfam: NADH-ubiquinone oxidoreductase MWFE subunit
InterPro: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1

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Chain: b
Length: 80 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02371 (Residues: 2-46; Coverage: 54%)
Gene name: NDUFA3
Pfam: NADH dehydrogenase 1 alpha subcomplex subunit 3
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

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Chain: c
Length: 49 amino acids
Theoretical weight: 5.84 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02376 (Residues: 28-76; Coverage: 65%)
Gene name: NDUFC1
Pfam: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
InterPro: NADH-ubiquinone oxidoreductase 1 subunit C1

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Chain: d
Length: 114 amino acids
Theoretical weight: 11.99 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02827 (Residues: 29-97; Coverage: 58%)
Gene name: NDUFC2
Pfam: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
InterPro: NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2

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Chain: e
Length: 106 amino acids
Theoretical weight: 12.69 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02379 (Residues: 1-106; Coverage: 100%)
Gene name: NDUFS5
Pfam: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
InterPro: NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5

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Chain: f
Length: 57 amino acids
Theoretical weight: 6.98 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02378 (Residues: 1-57; Coverage: 100%)
Gene name: NDUFB1
Pfam: MNLL subunit
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1

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Chain: g
Length: 125 amino acids
Theoretical weight: 14.47 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q8HXG5 (Residues: 30-154; Coverage: 81%)
Gene name: NDUFB11
Pfam: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
InterPro: NADH:ubiquinone oxidoreductase, ESSS subunit

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Chain: h
Length: 134 amino acids
Theoretical weight: 12.61 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02380 (Residues: 53-91; Coverage: 21%)
Gene name: NDUFB5
InterPro: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

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Chain: i
Length: 106 amino acids
Theoretical weight: 10.23 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02367 (Residues: 7-33; Coverage: 21%)
Gene name: NDUFB6
InterPro: NADH dehydrogenase 1, beta subcomplex, subunit 6

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Chain: k
Length: 74 amino acids
Theoretical weight: 6.32 KDa
Source organism: Bos taurus

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Chain: l
Length: 118 amino acids
Theoretical weight: 10.06 KDa
Source organism: Bos taurus

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Chain: m
Length: 118 amino acids
Theoretical weight: 13.42 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P48305 (Residues: 33-129; Coverage: 75%)
Gene name: NDUFB4
Pfam: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
InterPro: NADH:ubiquinone oxidoreductase, subunit NDUFB4

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Chain: n
Length: 166 amino acids
Theoretical weight: 19.25 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02369 (Residues: 11-137; Coverage: 71%)
Gene names: NDUFB9, UQOR22
Pfam: Complex 1 protein (LYR family)
InterPro:

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Chain: o
Length: 58 amino acids
Theoretical weight: 7.58 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02368 (Residues: 58-115; Coverage: 42%)
Gene name: NDUFB7
Pfam: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7

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Chain: p
Length: 169 amino acids
Theoretical weight: 16.91 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02373 (Residues: 77-143; Coverage: 38%)
Gene name: NDUFB10
Pfam: NADH-ubiquinone oxidoreductase subunit 10
InterPro:

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Chain: q
Length: 138 amino acids
Theoretical weight: 16.31 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: O97725 (Residues: 2-139; Coverage: 95%)
Gene name: NDUFA12
Pfam: NADH ubiquinone oxidoreductase subunit NDUFA12
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

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Chain: r
Length: 87 amino acids
Theoretical weight: 7.42 KDa
Source organism: Bos taurus

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