5ld8

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 435 amino acids
Theoretical weight: 45.4 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WQD9 (Residues: 2-416; Coverage: 100%)
Gene names: MTCY427.26, Rv2245, kasA
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P31
Unit cell:
a: 77.338Å b: 77.338Å c: 147.675Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.161 0.186
Expression system: Escherichia coli BL21(DE3)