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HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

Source organism: Homo sapiens
Biochemical function: L-ascorbic acid binding
Biological process: not assigned
Cellular component: not assigned

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EC 1.14.11.29: Hypoxia-inducible factor-proline dioxygenase

Reaction catalysed:
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2)
Systematic name:
Hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Alternative Name(s):
  • HIF hydroxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13640
Domain description: 2OG-Fe(II) oxygenase superfamily
Occurring in:
  1. Egl nine homolog 1
The deposited structure of PDB entry 5lbe contains 1 copy of Pfam domain PF13640 (2OG-Fe(II) oxygenase superfamily) in Egl nine homolog 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR044862
Domain description: Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Occurring in:
  1. Egl nine homolog 1
IPR005123
Domain description: Oxoglutarate/iron-dependent dioxygenase
Occurring in:
  1. Egl nine homolog 1
IPR006620
Domain description: Prolyl 4-hydroxylase, alpha subunit
Occurring in:
  1. Egl nine homolog 1

Structure domain

CATH CATH domain
2.60.120.620
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: q2cbj1_9rhob like domain
Occurring in:
  1. Egl nine homolog 1
The deposited structure of PDB entry 5lbe contains 1 copy of CATH domain 2.60.120.620 (Jelly Rolls) in Egl nine homolog 1. Showing 1 copy in chain A.

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