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HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

X-ray diffraction
1.749Å resolution
PDB entry 5lbe coloured by chain, front view.
PDB entry 5lbe coloured by chain, side view.
PDB entry 5lbe coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Egl nine homolog 1
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Multimeric state: monomeric
Accessible surface area: 11325.0 Å2
Buried surface area: 916.46 Å2
Dissociation area: 70.35 Å2
Dissociation energy (ΔGdiss): 0.73 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190450

Macromolecules

Egl nine homolog 1
Chain: A
Length: 252 amino acids
Theoretical weight: 28.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9GZT9 (Residues: 181-426; Coverage: 58%)
Gene names: C1orf12, EGLN1, PNAS-118, PNAS-137
Pfam: 2OG-Fe(II) oxygenase superfamily
InterPro:
CATH: q2cbj1_9rhob like domain
Egl nine homolog 1 in PDB entry 5lbe, assembly 1, front view.
Egl nine homolog 1 in PDB entry 5lbe, assembly 1, side view.
Egl nine homolog 1 in PDB entry 5lbe, assembly 1, top view.
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