› 5l9e

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER

Released:
DOI: 10.2210/pdb5l9e/pdb
PDB 5l9e coloured by chain and viewed from the front.
PDB 5l9e coloured by chain and viewed from the side.
PDB 5l9e coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Vallade M, Langlois d'Estaintot B, Granier T, Huc I

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

5 bound ligands:
Ligand ZN 27 x ZN
Ligand 6H0 4 x 6H0
Ligand QUJ 8 x QUJ
Ligand QVE 8 x QVE
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Unit cell:
a: 125.972Å b: 75.14Å c: 141.098Å
α: 90° β: 100.08° γ: 90°
R-values:
R R work R free
0.244 0.242 0.273
Expression system: Escherichia coli BL21(DE3)

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