5l6p

X-ray diffraction
2.26Å resolution

EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 6)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-B receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54753 (Residues: 616-910; Coverage: 31%)
Gene names: EPHB3, ETK2, HEK2, TYRO6
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 47.24Å b: 56.95Å c: 126.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.232
Expression system: Escherichia coli