X-ray diffraction
3.09Å resolution

Crystal structure of human dimethylglycine-dehydrogenase


Function and Biology Details

Reaction catalysed:
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dimethylglycine dehydrogenase, mitochondrial Chains: A, B

Ligands and Environments

Cofactor: Ligand FAD 2 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 83.377Å b: 119.868Å c: 86.466Å
α: 90° β: 92.58° γ: 90°
R R work R free
0.184 0.179 0.269
Expression system: Komagataella phaffii