› 5l44

X-ray diffraction
1.75Å resolution

Structure of K-26-DCP in complex with the K-26 tripeptide

Released:
DOI: 10.2210/pdb5l44/pdb
PDB 5l44 coloured by chain and viewed from the front.
PDB 5l44 coloured by chain and viewed from the side.
PDB 5l44 coloured by chain and viewed from the top.
Source organism: Astrosporangium hypotensionis K-26
Primary publication:
Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.
Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR
OpenAccess logo FEBS J 283 4357-4369 (2016)
PMID: 27754586

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase_M3 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 683 amino acids
Theoretical weight: 76.6 KDa
Source organism: Astrosporangium hypotensionis K-26
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A1L1QK30 (Residues: 1-630; Coverage: 100%)
Sequence domains: Peptidase family M3
Structure domains: Neurolysin; domain 3

Ligands and Environments

4 bound ligands:
Ligand ZN 2 x ZN
Ligand MG 4 x MG
Ligand SO4 2 x SO4
Ligand K26 2 x K26
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 61.58Å b: 66.94Å c: 102Å
α: 97.72° β: 90.71° γ: 117.37°
R-values:
R R work R free
0.187 0.185 0.213
Expression system: Escherichia coli BL21(DE3)

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Citations

1 citations in other articles

Synthesis and biological activity of dehydrophos derivatives.
Jiménez-Andreu et al. (2019)